Aleksandar uhrin biography of george michael
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Published in final edited form as: Mol Immunol. Jul 15;61(2)– doi: /
Abstract
Age-related macular degeneration (AMD) is a major cause of visual impairment in the western world. It is characterized by the presence of lipoproteinaceous deposits (drusen) in the inner layers of the retina. Immunohistochemistry studies identified deposition of complement proteins in the drusen as well as in the choroid. In the last decade, genetic studies have linked both common and rare variants in proteins of the complement system to increased risk of development of AMD. Here, we review the variants described to date and discuss the functional implications of dysregulation of the alternative pathway of complement in AMD.
Keywords: Age-related macular degeneration, complement system, alternative pathway, genetic variants
1. Introduction
Age-related macular degeneration (AMD) is the leading cause of vision loss in the developed world with approximat
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_3_Uhrin
Dorottya Uhrin
Eötvös Loránd University, School for Historical Studies, Medieval Hungarian History Doctoral Program
The aim of this article is to survey the cult of St Katherine of Alexandria in towns of medieval Upper Hungary (today mostly in Slovakia). In the first part, I briefly summarize the origin of the veneration of St Katherine and the beginning of her cult in Hungary. The geographical scope of my own research is the Upper Hungarian region, mainly the towns. The veneration of St Katherine has left most traces in the towns settled by Germans. Some of her earliest churches were established by families of German origin in the thirteenth century. Interestingly, St Katherine’s cult became significant in several mining towns, presumably from the fourteenth century, and her popularity there suggests that she might have been venerated as a miners’ saint (together with St Barbara). The heyday of Katherine’s cult was the late Middle Ages, when her ve